A weaker number (2 b7 b3 or 6) can work great as a coexisting Reference Tone. This example uses the same notes (A B C D D# and E) and the same Key of "A" both times, but creates different sounds by changing the Reference Tone.
Just to be thorough, because truthfully it can give the impression that the lower (bass) guitar line is different in each example. It's not, I recorded it first and then overdubbed the two different perspectives. If they sound different it has only to do with "how" the melody notes are played.